Evaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in mice
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
27/05/2014
27/05/2014
01/08/2005
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Resumo |
Strychnos pseudoquina St. Hil. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects. © 2005 Pharmaceutical Society of Japan. |
Formato |
881-885 |
Identificador |
http://dx.doi.org/10.1248/cpb.53.881 Chemical and Pharmaceutical Bulletin, v. 53, n. 8, p. 881-885, 2005. 0009-2363 http://hdl.handle.net/11449/68357 10.1248/cpb.53.881 WOS:000231320700002 2-s2.0-24944567759 |
Idioma(s) |
eng |
Relação |
Chemical and Pharmaceutical Bulletin |
Direitos |
openAccess |
Palavras-Chave | #Alkaloid #Antiulcer activity #Strychnos pseudoquina #Toxic activity #piroxicam #plant extract #strychnos pseudoquina extract #unclassified drug #animal experiment #animal model #animal tissue #concentration response #controlled study #drug dose regimen #drug effect #drug isolation #drug screening #in vivo study #male #medicinal plant #mortality #mouse #nonhuman #phytochemistry #plant leaf #stomach mucosa #stomach protection #stomach ulcer #strychnos pseudoquina #Animals #Anti-Inflammatory Agents, Non-Steroidal #Drug Evaluation, Preclinical #Gastric Mucosa #Mice #Plant Extracts #Plant Leaves #Stomach Ulcer #Strychnos |
Tipo |
info:eu-repo/semantics/article |