Produtos naturais como candidatos a fármacos úteis no tratamento do mal de Alzheimer
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
27/05/2014
27/05/2014
01/07/2004
|
Resumo |
Alzheimer's disease (AD) is a progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms in some patients. Nowadays drug research and development are based on the cholinergic hypothesis that supports the cognition improvement by regulation of the synthesis and release of acetylcholine in the brain. There are only four commercial medicines approved for treatment of AD and natural products have played an important role in the research for new acetylcholinesterase inhibitors. |
Formato |
655-660 |
Identificador |
http://dx.doi.org/10.1590/S0100-40422004000400021 Quimica Nova, v. 27, n. 4, p. 655-660, 2004. 0100-4042 http://hdl.handle.net/11449/67779 10.1590/S0100-40422004000400021 S0100-40422004000400021 WOS:000223108900021 2-s2.0-15044356788 2-s2.0-15044356788.pdf |
Idioma(s) |
por |
Relação |
Química Nova |
Direitos |
openAccess |
Palavras-Chave | #Acetylcholinesterase #Alzheimer's disease #Natural products #11 hydroxygalantamine #9 o norgalantamine #acetylcholine #cholinesterase inhibitor #donepezil #galantamine #Ginkgo biloba extract #natural product #rivastigmine #tacrine #unclassified drug #acetylcholine release #Alzheimer disease #brain function #cholinergic activity #cognition #conference paper #degenerative disease #drug efficacy #drug indication #drug synthesis #economic aspect #hypothesis #neuropathology #regulatory mechanism #social aspect |
Tipo |
info:eu-repo/semantics/conferencePaper |