Search for Antifungal and Anticancer Compounds from Native Plant Species of Cerrado and Atlantic Forest


Autoria(s): Bolzani, Vanderlan da Silva; Young, Maria Claudia M.; Furlan, Maysa; Cavalheiro, Alberto José; Araújo, Angela Regina; Silva, Dulce Helena Siqueira; Lopes, Márcia Nasser
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

01/12/1999

Resumo

Bioactivity-guided fractionation of several bioactive extracts obtained from Cerrado and Atlantic Forest plant species led to the isolation of potent DNA-damaging piperidine 1-5 and guanidine alkaloids 6-9 from Cassia leptophylla and Pterogyne nitens respectively, two common Leguminosae from Atlantic Forest. By means of biotechnological approach on Maytenus aquifolium, a species from Cerrado, moderate DNA-damaging sesquiterpene pyridine alkaloid 10-11 was isolated. Bioassay-guided fractionation on Casearia sylvestris, a medicinal plant species found in Cerrado and Atlantic Forest, led to the isolation of clerodane diterpenes 12-13 which showed effect on DNA. In addition, we have reported several interesting potent antifungal iridoids: 1β-hydroxy-dihydrocornin (14), 1α-hydroxy-dihydrocornin (15), α-gardiol (16), β-gardiol (17), plumericin (18), isoplumericin (19), 11-O-trans-caffeoylteucrein (20); ester derivative: 2-methyl-4-hydroxy-butyl-caffeoate (21), amide N-[7-(3'.4'-methylenedioxyphenyl)-2Z, 4Z-heptadienoyl] pyrrolidine (22) and triterpene viburgenin (23).

Formato

180-186

Identificador

Anais da Academia Brasileira de Ciencias, v. 71, n. 2, p. 180-186, 1999.

0001-3765

http://hdl.handle.net/11449/66030

2-s2.0-0347183068

2-s2.0-0032612902

Idioma(s)

eng

Relação

Anais da Academia Brasileira de Ciências

Direitos

closedAccess

Palavras-Chave #Antifungal compounds #Atlantic Forest #Cerrado #DNA-damaging compounds
Tipo

info:eu-repo/semantics/article