Search for Antifungal and Anticancer Compounds from Native Plant Species of Cerrado and Atlantic Forest
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
27/05/2014
27/05/2014
01/12/1999
|
Resumo |
Bioactivity-guided fractionation of several bioactive extracts obtained from Cerrado and Atlantic Forest plant species led to the isolation of potent DNA-damaging piperidine 1-5 and guanidine alkaloids 6-9 from Cassia leptophylla and Pterogyne nitens respectively, two common Leguminosae from Atlantic Forest. By means of biotechnological approach on Maytenus aquifolium, a species from Cerrado, moderate DNA-damaging sesquiterpene pyridine alkaloid 10-11 was isolated. Bioassay-guided fractionation on Casearia sylvestris, a medicinal plant species found in Cerrado and Atlantic Forest, led to the isolation of clerodane diterpenes 12-13 which showed effect on DNA. In addition, we have reported several interesting potent antifungal iridoids: 1β-hydroxy-dihydrocornin (14), 1α-hydroxy-dihydrocornin (15), α-gardiol (16), β-gardiol (17), plumericin (18), isoplumericin (19), 11-O-trans-caffeoylteucrein (20); ester derivative: 2-methyl-4-hydroxy-butyl-caffeoate (21), amide N-[7-(3'.4'-methylenedioxyphenyl)-2Z, 4Z-heptadienoyl] pyrrolidine (22) and triterpene viburgenin (23). |
Formato |
180-186 |
Identificador |
Anais da Academia Brasileira de Ciencias, v. 71, n. 2, p. 180-186, 1999. 0001-3765 http://hdl.handle.net/11449/66030 2-s2.0-0347183068 2-s2.0-0032612902 |
Idioma(s) |
eng |
Relação |
Anais da Academia Brasileira de Ciências |
Direitos |
closedAccess |
Palavras-Chave | #Antifungal compounds #Atlantic Forest #Cerrado #DNA-damaging compounds |
Tipo |
info:eu-repo/semantics/article |