Bioactive guanidine alkaloids from Pterogyne nitens
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
27/05/2014
27/05/2014
01/12/1995
|
| Resumo |
Bioactivity-guided fractionation of a methanolic CHCl 3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC 12=9.3-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B 1 cells (IC 50=8.5-13.0 μg/ml). |
| Formato |
1683-1688 |
| Identificador |
http://dx.doi.org/10.1021/np50125a006 Journal of Natural Products, v. 58, n. 11, p. 1683-1688, 1995. 0163-3864 http://hdl.handle.net/11449/64664 10.1021/np50125a006 WOS:A1995TQ55100006 2-s2.0-0029610979 |
| Idioma(s) |
eng |
| Relação |
Journal of Natural Products |
| Direitos |
closedAccess |
| Palavras-Chave | #guanidine derivative #nitensidine #pterogynidine #pterogynine #unclassified drug #antineoplastic activity #bioassay #carbon nuclear magnetic resonance #cytotoxicity #dna repair #drug activity #drug isolation #drug structure #proton nuclear magnetic resonance |
| Tipo |
info:eu-repo/semantics/article |
