Sister-chromatid exchanges in β-thalassaemic patients under conditions of in vivo and in vitro depletion of folic acid


Autoria(s): Silva, A. E.; Manzato, A. J.; Varella-Garcia, M.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

02/07/1992

Resumo

In order to investigate the effect of folate depletion, lymphocyte sister-chromatid exchange (SCE) rates were compared among homozygous β-thalassaemic patients with low folic acid levels, heterozygous β-thalassaemic patients with normal folate levels and healthy persons with normal haemoglobin, in cultures with both normal and depleted folate conditions. Significantly higher SCE rates were found in homozygous patients in all assays, but the in vitro folate depletion did not induce an increase in SCE frequency in any group.

Formato

213-217

Identificador

http://dx.doi.org/10.1016/0165-7992(92)90098-3

Mutation Research - Mutation Research Letters, v. 282, n. 3, p. 213-217, 1992.

0165-7992

http://hdl.handle.net/11449/64248

10.1016/0165-7992(92)90098-3

2-s2.0-0026740527

Idioma(s)

eng

Relação

Mutation Research - Mutation Research Letters

Direitos

closedAccess

Palavras-Chave #β-Thalassaemia #Culture conditions #Follic acid #Sister-chromatid exchange #folic acid #beta thalassemia #clinical article #controlled study #heterozygote #homozygote #human #human cell #lymphocyte culture #priority journal #sister chromatid exchange #Adolescent #Adult #Analysis of Variance #Cells, Cultured #Child #Child, Preschool #Folic Acid Deficiency #Human #Infant #Lymphocytes #Sister Chromatid Exchange #Support, Non-U.S. Gov't #Thalassemia
Tipo

info:eu-repo/semantics/article