Effects of unilateral decortication on β-adrenergic receptors in the remaining cortex and in the hypothalamus of female rats
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
26/05/2014
26/05/2014
01/01/1986
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Resumo |
Many experiments have been performed to evaluate the physiological role of catecholaminergic mechanisms of gonadotropin release. The purpose of the present study was to determine the concentration of β-adrenoreceptors in the remaining (right) cerebral cortex and in right and left hypothalamic halves of hemi-decorticated female rats which exhibited elevated plasma gonadotropin levels as observed previously. The density of β-receptors was measured using a high-affinity β-adrenergic ligand, iodocyanopindolol (ICYP). Scatchard estimates were obtained for maximum binding (B(max) fmol/mg of tissues) from pooled cerebral cortical and hypothalamic tissue of animals under several experimental conditions after hemi-decortication and sham operation. There was an increase in β-adrenoreceptor density in the remaining (right) cerebral cortex at all times examined in hemi-decorticate in comparison with the sham-operated animals (7 days, +10.9%; 21 days, +8.4%; 90 days, +22%; and 90 days plus ovariectomy, +34.8%). The number of β-adrenoreceptors in the right hypothalamic half in hemi-decorticates decreased at 21 days (-42.20%) and then increased at 90 days (+76.63%) and 90 days plus ovariectomy (+51.75%) when compared with the left hypothalamic half. At the same time there were no significant changes in the sham-operated animals when comparing the receptor density in the right and left hypothalamic halves, respectively. Thus, our results suggest a direct adrenergic pathway by which the left cortex can influence the right cortex and a crossed pathway to the contralateral hypothalamus changing adrenergic activity which can alter the β-adrenergic receptor binding capacity in the hypothalamus. |
Formato |
11-16 |
Identificador |
http://dx.doi.org/10.1016/0006-8993(86)91213-8 Brain Research, v. 384, n. 1, p. 11-16, 1986. 0006-8993 http://hdl.handle.net/11449/63759 10.1016/0006-8993(86)91213-8 2-s2.0-0022451485 |
Idioma(s) |
eng |
Relação |
Brain Research |
Direitos |
closedAccess |
Palavras-Chave | #beta adrenergic receptor #cyanoiodopindolol #cyanopindolol i 125 #propranolol #radioisotope #animal cell #animal experiment #brain cortex #central nervous system #decortication #drug receptor binding #endocrine system #estrus #female genital system #hypothalamus #nonhuman #ovariectomy #pharmacokinetics #priority journal #rat #rhinencephalon #Animal #Cerebral Cortex #Female #Hypothalamus #Laterality #Radioligand Assay #Rats #Rats, Inbred Strains #Receptors, Adrenergic, beta #Support, Non-U.S. Gov't #Support, U.S. Gov't, P.H.S. #Time Factors |
Tipo |
info:eu-repo/semantics/article |