Quantitative Phase Analyses Through The Rietveld Method with X-Ray Powder Diffraction Data of Heat-Treated Carbamazepine Form III


Autoria(s): Antonio, Selma Gutierrez; Benini, Fernanda Ribeiro; Ferreira, Fabio Furlan; Pires Rosa, Paulo Cesar; Paiva-Santos, Carlos de Oliveira
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/07/2011

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

The present work shows that the heated carbamazepine (CBZ) powder form III can be described as purely triclinic form I or a mixture of triclinic form I and monoclinic form III, depending on the resolution of the X-ray diffraction equipment used. Visual identification of the minor phase is possible when high-resolution synchrotron light is used. Quantitative phase analyses of CBZ forms I and III, after thermal treatment, were performed by using both synchrotron and conventional copper rotating anode X-ray powder diffraction data and the Rietveld method. Also, the Rietveld method could be adequately applied to determine the phase percentage in the heated material, even when usual resolution data are acquired. (C) 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100: 2658-2664, 2011

Formato

2658-2664

Identificador

http://dx.doi.org/10.1002/jps.22482

Journal of Pharmaceutical Sciences. Malden: Wiley-blackwell, v. 100, n. 7, p. 2658-2664, 2011.

0022-3549

http://hdl.handle.net/11449/41482

10.1002/jps.22482

WOS:000290725500013

Idioma(s)

eng

Publicador

Wiley-Blackwell

Relação

Journal of Pharmaceutical Sciences

Direitos

closedAccess

Palavras-Chave #X-ray powder diffractometry #polymorphism #crystallography #crystal structure #solid-state stability #quantitative phase analysis #synchrotron #carbamazepine #Rietveld method
Tipo

info:eu-repo/semantics/article