Lithium thiazolidine-4-carboxylate: Synthesis, spectroscopic characterization and preliminary in vitro cytotoxic studies in human HeLa cells
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
20/05/2014
20/05/2014
01/12/2008
|
| Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Processo FAPESP: 07/56317-1 Processo FAPESP: 06/55367-2 A new water-soluble lithium Salt of thiazolidine-4-carboxylic acid was synthesized and characterized by chemical and spectroscopic techniques, Elemental and mass spectrometric (ESI-MS) analyses of the solid compound fit to the composition LiC(4)H(6)NSO(2). (1)H, (13)C nuclear magnetic resonance (NMR). [(1)H-(15)N] NMR and infrared (IR) analyses permitted to elucidate the structure of the compound. Biological activity was evaluated by cytotoxic analysis using HeLa cells. Determination of cell death was assessed using a tetrazolium Salt colorimetric assay, which reflects the cells viability. (C) 2008 Elsevier B.V. All rights reserved. |
| Formato |
929-931 |
| Identificador |
http://dx.doi.org/10.1016/j.saa.2008.02.013 Spectrochimica Acta Part A-molecular and Biomolecular Spectroscopy. Oxford: Pergamon-Elsevier B.V. Ltd, v. 71, n. 3, p. 929-931, 2008. 1386-1425 http://hdl.handle.net/11449/39905 10.1016/j.saa.2008.02.013 WOS:000261118400032 |
| Idioma(s) |
eng |
| Publicador |
Pergamon-Elsevier B.V. Ltd |
| Relação |
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy |
| Direitos |
closedAccess |
| Palavras-Chave | #Thiazolidine-4-carboxylic acid #Infrared spectroscopy #NMR spectroscopy #Cytotoxicity |
| Tipo |
info:eu-repo/semantics/article |
