Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara .1.
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/10/1996
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Resumo |
The anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD(50) of t-DCTN was 555.0 mg/kg (p.o.) for mice. |
Formato |
402-404 |
Identificador |
http://dx.doi.org/10.1055/s-2006-957925 Planta Medica. Stuttgart: Georg Thieme Verlag, v. 62, n. 5, p. 402-404, 1996. 0032-0943 http://hdl.handle.net/11449/39058 10.1055/s-2006-957925 WOS:A1996VQ03600004 |
Idioma(s) |
eng |
Publicador |
Georg Thieme Verlag |
Relação |
Planta Medica |
Direitos |
closedAccess |
Palavras-Chave | #Croton cajucara #Euphorbiaceae #trans-dehydrocrotonin #19-nor-clerodane diterpene #anti-inflammatory and antinociceptive |
Tipo |
info:eu-repo/semantics/article |