Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA(2) from Bothrops asper venom
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
20/05/2014
20/05/2014
01/12/2004
|
| Resumo |
Suramin is a highly charged polysulfonated napthylurea that interferes in a number of physiologically relevant processes such as myotoxicity, blood coagulation and several kinds of cancers. This synthetic compound was complexed with a myotoxic Lys49 PLA(2) from Bothrops asper venom and crystallized by the hanging-drop vapor diffusion method at 18 degreesC. The crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit cell parameters a=49.05, b=63.84 and c=85.67 Angstrom, Diffraction data was collected to 1.78 Angstrom. (C) 2004 Elsevier B.V. All rights reserved. |
| Formato |
83-85 |
| Identificador |
http://dx.doi.org/10.1016/j.bbapap.2004.08.009 Biochimica Et Biophysica Acta-proteins and Proteomics. Amsterdam: Elsevier B.V., v. 1703, n. 1, p. 83-85, 2004. 1570-9639 http://hdl.handle.net/11449/37254 10.1016/j.bbapap.2004.08.009 WOS:000225621800010 |
| Idioma(s) |
eng |
| Publicador |
Elsevier B.V. |
| Relação |
Biochimica et Biophysica Acta: Proteins and Proteomics |
| Direitos |
closedAccess |
| Palavras-Chave | #suramin #myotoxicity #snake venom #Lys49 PLA(2)s #X-ray diffraction |
| Tipo |
info:eu-repo/semantics/article |
