Biological activities of constituents from Psychotria spectabilis


Autoria(s): Benevides, PJC; Young, MCM; Bolzani, Vanderlan da Silva
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/12/2004

Resumo

In a biological and phytochemical study on the leaves of Psychotria spectabilis Steyerm., seven compounds were isolated and identified from the CHCl3/MeOH (2:1, v/v) and MeOH extracts. Among the isolates were two diterpenes, solidagenone and deoxysolidagenone; three coumarins, coumarin, umbelliferone, and psoralene; and two flavonols, quercetin and quercetrin. Biological evaluations showed that diterpenes and coumarins exhibited antifungal activity against the filamentous fungi Cladosporium cladosporioides (Fresen) de Vries and C sphaerospermum Penzig. Solidagenone and psoralene also displayed selective cytotoxic activity against Rad 52Y mutant yeast strain of Saccharomyces cerevisiae. In this paper, the isolation, structure elucidation, and bioactivity results of these compounds are reported.

Formato

565-569

Identificador

http://dx.doi.org/10.1080/13880200490901780

Pharmaceutical Biology. Philadelphia: Taylor & Francis Inc., v. 42, n. 8, p. 565-569, 2004.

1388-0209

http://hdl.handle.net/11449/36538

10.1080/13880200490901780

WOS:000227438300001

Idioma(s)

eng

Publicador

Taylor & Francis Inc

Relação

Pharmaceutical Biology

Direitos

closedAccess

Palavras-Chave #antifungal compounds #bioactivity-directed isolation #DNA-damaging activities #Psychotria spectabilis #Rubiaceae
Tipo

info:eu-repo/semantics/article