Ventromedial hypothalamus lesions increase the dipsogenic responses and reduce the pressor responses to median preoptic area activation
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
---|---|
Data(s) |
20/05/2014
20/05/2014
01/08/1997
|
Resumo |
In this study, we investigated the participation of adrenergic receptors of the median preoptic area (MnPO) and the participation of ventromedial hypothalamus (VMH) in angiotensin II- (ANG II)-induced water intake and presser responses. Male rats with sham or electrolytic VMH lesions and a stainless steel cannula implanted into the MnPO were used. Noradrenaline, clonidine (an alpha(2)-adrenergic receptor agonist), or phenylephrine (an alpha(1)-adrenergic receptor agonist) injected into the MnPO of sham-lesioned rats reduced water ingestion induced by ANG II injected into the same area. In VMH-lesioned rats ANG II-induced water intake increased with a previous injection of noradrenaline, phenylephrine, or isoproterenol. The presser response induced by ANG II injected into the MnPO was reduced in VMH-lesioned rats, whereas the presser response induced by clonidine was abolished. Previous treatment with noradrenaline and phenylephrine into the MnPO of sham-lesioned rats produced a presser response, and a hypotensive response was obtained with the previous administration of noradrenaline, phenylephrine or isoproterenol into the MnPO of VMH-lesioned rats. These results show that VMH is essential for the dipsogenic and presser responses induced by adrenergic and angiotensinergic activation of the MnPO in rats. (C) 1997 Elsevier B.V. |
Formato |
311-316 |
Identificador |
http://dx.doi.org/10.1016/S0031-9384(97)88986-X Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 62, n. 2, p. 311-316, 1997. 0031-9384 http://hdl.handle.net/11449/35627 10.1016/S0031-9384(97)88986-X WOS:A1997XN41000013 |
Idioma(s) |
eng |
Publicador |
Elsevier B.V. |
Relação |
Physiology & Behavior |
Direitos |
closedAccess |
Palavras-Chave | #water intake #arterial pressure #ANG II #adrenergic agonists #MnPO #VMH |
Tipo |
info:eu-repo/semantics/article |