Antiplasmodial activity of aryltetralone lignans from Holostylis reniformis
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/07/2007
|
Resumo |
Extracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum. The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7 ' R,8S,8 ' S)-3 ',4 '-methylenedioxy-4,5-dimethoxy-2,7 '-cyclolignan-7-one, were isolated and tested in vitro against P. falciparum. The three most active lignans showed 50% inhibitor concentrations of <= 0.32 mu M. An evaluation of minimum lethal dose (30%) values showed low toxicity for these lignans in a hepatic cell line (Hep G2A16). Therefore, these compounds are potential candidates for the development of antimalarial drugs. |
Formato |
2346-2350 |
Identificador |
http://dx.doi.org/10.1128/AAC.01344-06 Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 51, n. 7, p. 2346-2350, 2007. 0066-4804 http://hdl.handle.net/11449/35268 10.1128/AAC.01344-06 WOS:000247665800008 WOS000247665800008.pdf |
Idioma(s) |
eng |
Publicador |
Amer Soc Microbiology |
Relação |
Antimicrobial Agents and Chemotherapy |
Direitos |
openAccess |
Tipo |
info:eu-repo/semantics/article |