Antiplasmodial activity of aryltetralone lignans from Holostylis reniformis


Autoria(s): de Andrade-Neto, Valter F.; da Silva, Tito; Xavier Lopes, Lucia M.; do Rosario, Virgilio E.; de Pilla Varotti, Fernando; Krettli, Antoniana U.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/07/2007

Resumo

Extracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum. The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7 ' R,8S,8 ' S)-3 ',4 '-methylenedioxy-4,5-dimethoxy-2,7 '-cyclolignan-7-one, were isolated and tested in vitro against P. falciparum. The three most active lignans showed 50% inhibitor concentrations of <= 0.32 mu M. An evaluation of minimum lethal dose (30%) values showed low toxicity for these lignans in a hepatic cell line (Hep G2A16). Therefore, these compounds are potential candidates for the development of antimalarial drugs.

Formato

2346-2350

Identificador

http://dx.doi.org/10.1128/AAC.01344-06

Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 51, n. 7, p. 2346-2350, 2007.

0066-4804

http://hdl.handle.net/11449/35268

10.1128/AAC.01344-06

WOS:000247665800008

WOS000247665800008.pdf

Idioma(s)

eng

Publicador

Amer Soc Microbiology

Relação

Antimicrobial Agents and Chemotherapy

Direitos

openAccess

Tipo

info:eu-repo/semantics/article