Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/01/2007
|
Resumo |
One new erythrinian alkaloid derivative, (+)-11 alpha-hydroxyerythravine (1), and the known (+)-erythravine (2) and (+)-alpha-hydroxyerysotrine (3) were isolated from the flowers of Erythrina mulungu. Their structures were determined by spectroscopic/spectrometric data interpretation of H-1, C-13, and 2D NMR and MS experiments. The relative configuration was established by NOESY analysis, while the conformation adopted by these molecules was evaluated through molecular modeling studies and coupling constants obtained by NMR analysis. Furthermore, the anxiolytic effects of the E. mulungu aqueous alcoholic crude extract and of the purified alkaloids were evaluated using the elevated T-maze test. |
Formato |
48-53 |
Identificador |
http://dx.doi.org/10.1021/np060254j Journal of Natural Products. Washington: Amer Chemical Soc, v. 70, n. 1, p. 48-53, 2007. 0163-3864 http://hdl.handle.net/11449/34065 10.1021/np060254j WOS:000243734900011 |
Idioma(s) |
eng |
Publicador |
Amer Chemical Soc |
Relação |
Journal of Natural Products |
Direitos |
closedAccess |
Tipo |
info:eu-repo/semantics/article |