Differential pulse polarographic determination of clotrimazole after derivatization with Procion Red HE-3B


Autoria(s): Pereira, F. C.; Zanoni, Maria Valnice Boldrin; Guaratini, CCI; Fogg, A. G.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/01/2002

Resumo

Clotrimazole was shown to react at room temperature in Britton Robinson buffer pH 2 with the reactive dye Procion Red HE-3B. The product exhibited a differential pulse polarographic peak at -0.38 V, which was well separated from the peaks of the reactive dye at -0.08, -0.80 and -0.95 V, and this allowed the indirect determination of clotrimazole in the presence of excess of the reactive dye. The method has been applied satisfactorily to the determination of clotrimazole in pharmaceutical formulations, calibration graphs are rectilinear up to at least 40 mug ml(-1). The detection limit was calculated to be 2.6 mug ml(-1) (3 sigma). (C) 2002 Elsevier B.V. B.V. All rights reserved.

Formato

201-208

Identificador

http://dx.doi.org/10.1016/S0731-7085(01)00526-X

Journal of Pharmaceutical and Biomedical Analysis. Oxford: Pergamon-Elsevier B.V., v. 27, n. 1-2, p. 201-208, 2002.

0731-7085

http://hdl.handle.net/11449/33321

10.1016/S0731-7085(01)00526-X

WOS:000172456000024

Idioma(s)

eng

Publicador

Elsevier B.V.

Relação

Journal of Pharmaceutical and Biomedical Analysis

Direitos

closedAccess

Palavras-Chave #clotrimazole #differential pulse polarography #Procion Red HE-3B dye
Tipo

info:eu-repo/semantics/article