Acetylated DNA-damaging clerodane diterpenes from Casearia sylvestris
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
20/05/2014
20/05/2014
01/11/1998
|
| Resumo |
In addition to the known diterpene casearin G (1), two new clerodane diterpene casearins type, casearin S (2) and casearin T (3), were isolated from an acetylated bioactive CH2Cl2/MeOH extract from leaves of Casealia sylvestris. The diterpenes 1-3 exhibited moderate but selective activity towards the DNA-repair deficient yeast Saccharomyces cerevisiae mutants RAD 52YK and RS 321. The structures of 1-3 were established on the basis of NMR spectroscopic experiments (C) 1998 Elsevier B.V. Ltd. All rights reserved. |
| Formato |
1659-1662 |
| Identificador |
http://dx.doi.org/10.1016/S0031-9422(98)00249-0 Phytochemistry. Oxford: Pergamon-Elsevier B.V., v. 49, n. 6, p. 1659-1662, 1998. 0031-9422 http://hdl.handle.net/11449/32749 10.1016/S0031-9422(98)00249-0 WOS:000077480300027 |
| Idioma(s) |
eng |
| Publicador |
Elsevier B.V. |
| Relação |
Phytochemistry |
| Direitos |
closedAccess |
| Palavras-Chave | #Casearia sylvestris #flacourtiaceae #diterpene #clerodane #casearins #DNA-damaging activity |
| Tipo |
info:eu-repo/semantics/article |
