Antimalarial use of volatile oil from leaves of Virola surinamensis (Rol.) Warb. by Waiapi Amazon Indians


Autoria(s): Lopes, N. P.; Kato, M. J.; Andrade, EHD; Maia, JGS; Yoshida, M.; Planchart, A. R.; Katzin, A. M.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/11/1999

Resumo

The Amazon Indians Waiapi living in the West of Amapa State of Brazil, treat malaria with an inhalation of vapor obtained from leaves of Viola surinamensis. The essential oil obtained from adult and plantlet leaves was analyzed by GC/MS and 11 monoterpenes, 11 sesquiterpenes and three phenylpropanoids were identified. Plantlet essential oil caused 100% of growth inhibition after 48 h in the development of the young trophozoite to schizont stage and the sesquiterpene nerolidol (100 mu g/ml) was identified as one of the active constituents (100% of growth inhibition was obtained). In addition, examination of [(UC)-C-14]-glucose incorporation showed that activity of nerolidol is related to the inhibition of glycoprotein biosynthesis. (C) 1999 Elsevier B.V. Ireland Ltd. All rights reserved.

Formato

313-319

Identificador

http://dx.doi.org/10.1016/S0378-8741(99)00072-0

Journal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 67, n. 3, p. 313-319, 1999.

0378-8741

http://hdl.handle.net/11449/31608

10.1016/S0378-8741(99)00072-0

WOS:000083283800008

Idioma(s)

eng

Publicador

Elsevier B.V.

Relação

Journal of Ethnopharmacology

Direitos

closedAccess

Palavras-Chave #essential oil #malaria #Myristicaceae #Plasmodium falciparum #Virola surinamensis #Waiapi Indians
Tipo

info:eu-repo/semantics/article