SEX-RELATED DIFFERENCES IN THE ANALGESIC RESPONSE TO THE RAT TAIL IMMERSION TEST


Autoria(s): Molina, N.; Bedrandecastro, MTB; Bedrandecastro, J. C.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/07/1994

Resumo

The analgesic response was evaluated by the tail immersion test in adult male (N = 30), female (N = 21) and androgenized female Wistar rats (N = 15). The reaction time for tail withdrawal from the hot water bath was faster for male than for female rats (3.48 +/- 0.12 vs 6.46 +/- 0.42 s). The reaction time of androgenized female rats was similar to that of male rats (3.08 +/- 0.16 s). Blockade of opiate receptors with naloxone (2 mg/kg, ip) decreased the sensitivity to the noxious stimuli in males (4.08 +/- 0.10 s) and in androgenized females (3.69 +/- 0.19 s) but increased it in female rats (5.01 +/- 0.41 s). These data show sex-related differences in the analgesic response evaluated by the tail immersion test and indicate that administration of androgens to newborn female rats affects their pain sensitivity.

Formato

1669-1672

Identificador

http://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso

Brazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 27, n. 7, p. 1669-1672, 1994.

0100-879X

http://hdl.handle.net/11449/31502

WOS:A1994PA55200021

Idioma(s)

eng

Publicador

Associação Brasileira de Divulgação Científica (ABRADIC)

Relação

Brazilian Journal of Medical and Biological Research

Direitos

closedAccess

Palavras-Chave #PAIN #SEX DIFFERENCE #TAIL IMMERSION TEST #NEONATAL ANDROGENIZATION
Tipo

info:eu-repo/semantics/article