Further bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilis


Autoria(s): Viegas, C.; Bolzani, Vanderlan da Silva; Furlan, Maysa; Barreiro, E. J.; Young, MCM; Tomazela, D.; Eberlin, M. N.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/05/2004

Resumo

The flowers of Cassia spectabilis yielded three new piperidine alkaloids, (-)-3-O-acetylspectaline (1), (-)-7-hydroxyspectaline (2), and iso-6-spectaline (3), together with the known (-)-spectaline (4). The green fruits of this plant were also investigated, resulting in the isolation of 1 and 4. Their structures were elucidated using a combination of multidimensional NMR and MS techniques, and relative stereochemistries were established by NOESY correlations and analysis of coupling constants. The DNA-damaging activity of these compounds was evaluated using a mutant yeast, Saccharomyces cerevisiae, assay.

Formato

908-910

Identificador

http://dx.doi.org/10.1021/np0303963

Journal of Natural Products. Washington: Amer Chemical Soc, v. 67, n. 5, p. 908-910, 2004.

0163-3864

http://hdl.handle.net/11449/31389

10.1021/np0303963

WOS:000221804700034

Idioma(s)

eng

Publicador

Amer Chemical Soc

Relação

Journal of Natural Products

Direitos

closedAccess

Tipo

info:eu-repo/semantics/article