Lipoperoxidation and cyclooxygenase enzyme inhibitory piperidine alkaloids from Cassia spectabilis green fruits


Autoria(s): Viegas, Claudio; Silva, Dulce Helena Siqueira; Pivatto, Marcos; de Rezende, Amanda; Castro-Gamboa, Ian; Bolzani, Vanderlan da Silva; Nair, Muraleedharan G.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/12/2007

Resumo

Phytochernical work in the search for bioactive metabolites from the methanolic extract of Senna spectabilis green fruits led to the isolation of a new piperidine alkaloid, (+)-3-O-feruloylcassine (1), in addition to the known (-)-spectaline (2) and (-)-3-O-acetylspectaline (3). The isolates were submitted to in vitro evaluation of lipoperoxidation (LPO) and cyclooxygenase enzymes (COX-1 and -2) inhibitory properties and showed moderate antioxidant activities (40-70%) at 100 ppm when compared to commercial standards BHT and vitamin E and moderate inhibition of COX-1 (ca. 40%) and marginal inhibition of COX-2 enzymes (< 10%) at 100 ppm when compared to nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin, rofecoxib, and celecoxib, respectively.

Formato

2026-2028

Identificador

http://dx.doi.org/10.1021/np070312g

Journal of Natural Products. Washington: Amer Chemical Soc, v. 70, n. 12, p. 2026-2028, 2007.

0163-3864

http://hdl.handle.net/11449/30941

10.1021/np070312g

WOS:000252046700037

Idioma(s)

eng

Publicador

Amer Chemical Soc

Relação

Journal of Natural Products

Direitos

closedAccess

Tipo

info:eu-repo/semantics/article