The use of mitomycin C in caustic esophagitis in rats


Autoria(s): Bustamante, Thais França; Lourenção, Pedro Luiz Toledo de Arruda; Higa, Kátia Leitão; Silva, Amanda Pinter Carvalheiro da; Ortolan, Érika Veruska Paiva
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/02/2013

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

PURPOSE: To evaluate the topical effects of mitomycin C (MMC) in rats, with or without esophageal dilation, in different moments after esophageal caustic injury with NaOH10%. METHODS: Forty eight Wistar rats were divided into six groups: GS infusion of 0.9% saline solution in the esophagus; CG infusion of 0.9% saline solution in the esophagus, with temporary ligation of the organ; NTG induction of a caustic lesion without treatment; GmmcD0 MMC applied immediately after the caustic injury; GmmcD14 MMC applied 14 days after the caustic injury; Gdil+mmcD14 esophageal dilation and application of MMC 14 days after caustic injury. We performed contrast esophagograms of four animals from each group, seven and 21 days after the caustic injury. on day 28, all animals were sacrificed, and histopathological analyses were performed on the esophageal specimens. RESULTS: The contrast images showed total stenosis in NTG and GmmcD0, improving to partial stenosis in GmmcD0. In GmmcD14 and Gdil+mmcD14, two animals of each group improved to partial stenosis. By histopathological analysis, NTG and GmmcD14 presented intermediate damage and GmmcD0 and Gdil+mmcD14 severe damage. CONCLUSION: The use of mitomycin C had beneficial effects specially when applied immediately after the induction of esophageal lesions.

Formato

136-141

Identificador

http://dx.doi.org/10.1590/S0102-86502013000200009

Acta Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 2, p. 136-141, 2013.

0102-8650

http://hdl.handle.net/11449/29018

10.1590/S0102-86502013000200009

S0102-86502013000200009

WOS:000314365100009

S0102-86502013000200009.pdf

Idioma(s)

eng

Publicador

Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia

Relação

Acta Cirúrgica Brasileira

Direitos

openAccess

Palavras-Chave #Esophageal Stenosis #Mitomycin #Rats
Tipo

info:eu-repo/semantics/article