The use of mitomycin C in caustic esophagitis in rats
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/02/2013
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Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) PURPOSE: To evaluate the topical effects of mitomycin C (MMC) in rats, with or without esophageal dilation, in different moments after esophageal caustic injury with NaOH10%. METHODS: Forty eight Wistar rats were divided into six groups: GS infusion of 0.9% saline solution in the esophagus; CG infusion of 0.9% saline solution in the esophagus, with temporary ligation of the organ; NTG induction of a caustic lesion without treatment; GmmcD0 MMC applied immediately after the caustic injury; GmmcD14 MMC applied 14 days after the caustic injury; Gdil+mmcD14 esophageal dilation and application of MMC 14 days after caustic injury. We performed contrast esophagograms of four animals from each group, seven and 21 days after the caustic injury. on day 28, all animals were sacrificed, and histopathological analyses were performed on the esophageal specimens. RESULTS: The contrast images showed total stenosis in NTG and GmmcD0, improving to partial stenosis in GmmcD0. In GmmcD14 and Gdil+mmcD14, two animals of each group improved to partial stenosis. By histopathological analysis, NTG and GmmcD14 presented intermediate damage and GmmcD0 and Gdil+mmcD14 severe damage. CONCLUSION: The use of mitomycin C had beneficial effects specially when applied immediately after the induction of esophageal lesions. |
Formato |
136-141 |
Identificador |
http://dx.doi.org/10.1590/S0102-86502013000200009 Acta Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 2, p. 136-141, 2013. 0102-8650 http://hdl.handle.net/11449/29018 10.1590/S0102-86502013000200009 S0102-86502013000200009 WOS:000314365100009 S0102-86502013000200009.pdf |
Idioma(s) |
eng |
Publicador |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
Relação |
Acta Cirúrgica Brasileira |
Direitos |
openAccess |
Palavras-Chave | #Esophageal Stenosis #Mitomycin #Rats |
Tipo |
info:eu-repo/semantics/article |