Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/01/2010
|
Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA. |
Formato |
1291-1296 |
Identificador |
http://dx.doi.org/10.1590/S0100-40422010000600014 Química Nova. Sociedade Brasileira de Química, v. 33, n. 6, p. 1291-1296, 2010. 0100-4042 http://hdl.handle.net/11449/27620 10.1590/S0100-40422010000600014 S0100-40422010000600014 WOS:000281692900014 S0100-40422010000600014.pdf |
Idioma(s) |
eng |
Publicador |
Sociedade Brasileira de Química |
Relação |
Química Nova |
Direitos |
openAccess |
Palavras-Chave | #amodiaquine #guanine #adduct |
Tipo |
info:eu-repo/semantics/article |