Clinical and hematological alterations in dogs during experimental envenomation with Crotalus durissus terrificus venom and treated with antiophidic serum


Autoria(s): Nogueira, R. M. B.; Sakate, M.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/04/2006

Resumo

The present work aimed to evaluate the clinical and hematological aspects during experimental envenomation by Crotalus durissus terrificus in dogs treated with different antiophidic serum doses. Sixteen dogs were divided into two groups of eight animals each. Group I received 1mg/kg venom subcutaneously and 30mg antiophidic serum intravenously; Group II received 1mg/kg venom subcutaneously and 60mg antiophidic serum intravenously. In the clinical evaluation, we observed ataxia, moderate sedation, dilated pupils, sialorrhea, flaccid paralysis of mandibular muscles, and discreet edema at the site of venom inoculation. Evaluating red and white blood cells, we observed a decrease of hemoglobins, globular volume and erythrocytes, and an increase of plasmatic proteins, leukocytes, neutrophils, monocytes and lymphocytes. Clotting time increased and there was blood incoagulability with return to normal clotting time six hours after antiophidic serum administration. Animals treated with six antiophidic serum flasks had a faster recovery than the animals that received three serum flasks.

Formato

285-296

Identificador

http://dx.doi.org/10.1590/S1678-91992006000200010

Journal of Venomous Animals and Toxins including Tropical Diseases. Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, v. 12, n. 2, p. 285-296, 2006.

1678-9199

http://hdl.handle.net/11449/26914

10.1590/S1678-91992006000200010

S1678-91992006000200010

S1678-91992006000200010.pdf

Idioma(s)

eng

Publicador

Universidade Estadual Paulista (UNESP), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)

Relação

Journal of Venomous Animals and Toxins Including Tropical Diseases

Direitos

openAccess

Palavras-Chave #Crotalus durissus terrificus #dog #clinical aspects #hematological aspects #venom
Tipo

info:eu-repo/semantics/article