Acetylcholinesterase Inhibitory Pyridine Alkaloids of the Leaves of Senna multijuga


Autoria(s): Serrano, Maria A. R.; Pivatto, Marcos; Francisco, Welington; Danuello, Amanda; Regasini, Luis O.; Lopes, Elaine M. C.; Lopes, Márcia Nasser; Young, Maria C. M.; Bolzani, Vanderlan da Silva
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/03/2010

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Two unusual pyridine alkaloids, 7'-multijuguinone (1) and 12'-hydroxy-7'-multijuguinone none (2), were isolated front the leaves of Senna multijuga, together with the known flavonoid rutin. The structures of the new alkaloids were established oil the basis of spectroscopy data interpretation. Compounds I and 2 exhibited moderate in vitro acetylcholinesterase (AChE) inhibitory activity, in comparison With the standard compound physostiomine.

Formato

482-484

Identificador

http://dx.doi.org/10.1021/np900644x

Journal of Natural Products. Washington: Amer Chemical Soc, v. 73, n. 3, p. 482-484, 2010.

0163-3864

http://hdl.handle.net/11449/26079

10.1021/np900644x

WOS:000275885000036

Idioma(s)

eng

Publicador

Amer Chemical Soc

Relação

Journal of Natural Products

Direitos

closedAccess

Tipo

info:eu-repo/semantics/conferenceObject