Determination of 5-aminosalicylic acid in pharmaceutical formulations by square wave voltammetry at pencil graphite electrodes


Autoria(s): Uliana, Carolina V.; Yamanaka, Hideko; Garbellini, Gustavo S.; Salazar-Banda, Giancarlo R.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/01/2010

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Processo FAPESP: 06/50692-2

An analytical method for the determination of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA) in pharmaceutical formulations using square wave voltammetry at pencil graphite electrodes was developed. After the optimization of the experimental conditions, calibration curves were obtained in the linear concentration range from 9.78 × 10-7 to 7.25 × 10-5 mol L-1 resulting in a limit of detection of 2.12 ± 0.05 x 10-8 mol L-1. Statistical tests showed that the concentrations of 5-ASA in commercial tablets and enemas obtained with the proposed voltammetric method agreed with HPLC values at a 95% confidence level.

Formato

964-967

Identificador

http://dx.doi.org/10.1590/S0100-40422010000400036

Química Nova. Sociedade Brasileira de Química, v. 33, n. 4, p. 964-967, 2010.

0100-4042

http://hdl.handle.net/11449/25697

10.1590/S0100-40422010000400036

S0100-40422010000400036

WOS:000278322500036

S0100-40422010000400036.pdf

Idioma(s)

eng

Publicador

Sociedade Brasileira de Química

Relação

Química Nova

Direitos

openAccess

Palavras-Chave #5-aminosalicylic acid #pharmaceutical formulations #pencil graphite electrode
Tipo

info:eu-repo/semantics/article