Antinociceptive and anti-inflammatory activities of ethanolic extracts of Lychnophora species


Autoria(s): Guzzo, L. S.; Saude-Guimaraes, D. A.; Silva, A. C. A.; Lombardi, J. A.; Guimaraes, H. N.; Grabe-Guimaraes, A.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

30/09/2013

20/05/2014

30/09/2013

20/05/2014

28/02/2008

Resumo

Extracts from Lychnophora species are traditionally used in Brazil as anti-inflammatory, and to treat bruise, pain and rheumatism. The ethanolic extract of aerial parts of five species of Lychnophoras and one specie of Lychnophoriopsis were examined for the antinociceptive (hot-plate and writhing tests) and anti-inflammatory (carrageenan-induced paw oedema test) activity in mice, by oral and topical routes, respectively. In the hot-plate test, the Lychnophora pinaster (0.75 g/kg) and Lychnophora ericoides (1.50 g/kg) extracts significantly increased the time for licking of the paws. The species Lychnophora passerina, Lychnophoriopsis candelabrum and Lychnophora pinaster, using the dose of 0.75 g/kg, and Lychnophora ericoides and Lychnophora trichocarpha in both doses evaluated (0.75 and 1.50 g/kg) significantly reduced the number of writhes induced by acetic acid. The administration of Lychnophora pinaster and Lychnophora trichocarpha ointments, in both concentrations evaluated (5 and 10%, w/w), and Lychnophora passerina and Lychnophoriopsis candelabrum, in the concentration of 10%, significantly reduced the paw oedema measured 3 h after carrageenan administration, suggesting, for the first time, an anti-inflammatory activity upon topical administration of these species. The present work comparatively demonstrated the antinociceptive and anti-inflammatory activities of some Brazilian Lychnophoras. (C) 2007 Elsevier B.V. All rights reserved.

Formato

120-124

Identificador

http://dx.doi.org/10.1016/j.jep.2007.11.006

Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 116, n. 1, p. 120-124, 2008.

0378-8741

http://hdl.handle.net/11449/20366

10.1016/j.jep.2007.11.006

WOS:000253398000018

Idioma(s)

eng

Publicador

Elsevier B.V.

Relação

Journal of Ethnopharmacology

Direitos

closedAccess

Palavras-Chave #Lychnophoras #anti-inflammatory activity #carrageenan #antinociceptive activity #hot-plate test #writhing test
Tipo

info:eu-repo/semantics/article