Cytotoxicity of fipronil on mice liver cells
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/01/2012
|
Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Processo FAPESP: 06/52599-0 Processo FAPESP: 08/59020-0 In the present study, mice livers were examined following exposure to different doses of fipronil (15, 25, and 50 mg/kg). Histological and histochemical techniques were used to determine the cytotoxic potential of this compound and to assess the damage it caused to livers. Mice were divided into four groups: control group and groups I, II, and III were exposed to 15, 25, and 50 mg/kg fipronil, respectively. Our findings revealed cytological, morphohistological, and histochemical alterations in liver cells of animals from groups I, II, and III compared to group control animals. These changes included Kupffer-cell proliferation, hepatocyte hypertrophy, accumulation and distribution of proteins, polysaccharides, lipids, and vacuoles in the cytoplasm of hepatocytes, and congestion of blood vessels. These phenotypes mainly characterize the following: (a) autophagic processes, (b) steatosis, and (c) cell death by necrosis, which demonstrate the damage caused by fipronil on nontarget organisms in artificial conditions. Microsc. Res. Tech., 2012. (c) 2011 Wiley Periodicals, Inc. |
Formato |
28-35 |
Identificador |
http://dx.doi.org/10.1002/jemt.21018 Microscopy Research and Technique. Malden: Wiley-blackwell, v. 75, n. 1, p. 28-35, 2012. 1059-910X http://hdl.handle.net/11449/19791 10.1002/jemt.21018 WOS:000298599300005 |
Idioma(s) |
eng |
Publicador |
Wiley-Blackwell |
Relação |
Microscopy Research and Technique |
Direitos |
closedAccess |
Palavras-Chave | #Acaricide #autophagy #Histopathology #Pesticide #Toxicity |
Tipo |
info:eu-repo/semantics/article |