Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
20/05/2014
20/05/2014
01/02/2011
|
| Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Processo FAPESP: 04/07942-2 Processo FAPESP: 06/57122-6 Nigriventrine was isolated from the armed spider Phoneutria nigriventer, in which it constitutes about 0.4% of the total venom content. Its structure was determined to be [1,1`-(1-hydroxyhydrazine-1,2-diyl)bis(oxy)bis(4-hydroxy-2,6-dioxopiperidine-4 carboxylic acid)] by NMR, HR-ES/IMS and MS/MS methods. The intracerebroventricular application of nigriventrine in rat brain, followed by the detection of c-Fos protein expression, indicated that the compound was neuroactive in the motor cortex, sensory cortex, piriform cortex, median preoptic nucleus, dorsal endopiriform nucleus, lateral septal nucleus and hippocampus of rat brain. Nigriventrine causes convulsions in rats, even when peripherally applied. (c) 2010 Elsevier Ltd. All rights reserved. |
| Formato |
266-274 |
| Identificador |
http://dx.doi.org/10.1016/j.toxicon.2010.11.021 Toxicon. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 2, p. 266-274, 2011. 0041-0101 http://hdl.handle.net/11449/19670 10.1016/j.toxicon.2010.11.021 WOS:000287629400010 WOS000287629400010.pdf |
| Idioma(s) |
eng |
| Publicador |
Pergamon-Elsevier B.V. Ltd |
| Relação |
Toxicon |
| Direitos |
openAccess |
| Palavras-Chave | #Spider venom #Spectroscopy #Low molecular mass #Neurotoxin #Glutamate receptor #Natural product |
| Tipo |
info:eu-repo/semantics/article |
