Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera)
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/06/2004
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Resumo |
Four antimicrobial peptides were purified from Royal Jelly of honeybees, by using reverse phase-HPLC and sequenced by using Q-Tof-MS/MS: PFKLSLHL-NH2 (Jelleine-I), TPFKLSLHL-NH2 (Jelleine-II), EPFKLSLHL-NH2 (Jelleine-III), and TPFKLSLH-NH2 (Jelleine-IV). The peptides were synthesized on-solid phase, purified and submitted to different biological assays: antimicrobial activity, mast cell degranulating activity and hemolysis. The Jelleines-I-III presented exclusively antimicrobial activities against yeast, Gram+ and Gram- bacteria; meanwhile, Jelleine-IV was not active in none of the assays performed. These peptides do not present any similarity with the other antimicrobial peptides from the honeybees; they are produced constitutively by the workers and secreted into Royal Jelly. (C) 2004 Elsevier B.V. All rights reserved. |
Formato |
919-928 |
Identificador |
http://dx.doi.org/10.1016/j.peptides.2004.03.016 Peptides. New York: Elsevier B.V., v. 25, n. 6, p. 919-928, 2004. 0196-9781 http://hdl.handle.net/11449/19600 10.1016/j.peptides.2004.03.016 WOS:000222395900003 |
Idioma(s) |
eng |
Publicador |
Elsevier B.V. |
Relação |
Peptides |
Direitos |
closedAccess |
Palavras-Chave | #royal jelly #Africanized honeybees #Apis mellifera #mass spectrometry #antimicrobial peptides |
Tipo |
info:eu-repo/semantics/article |