Natural killer activity in the experimental privational rickets
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/05/2002
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Resumo |
To study the 'in vivo' importance of vitamin D on the natural killer (NK) activity, rats were submitted to privational rickets induced by a diet deficient in vitamin D and phosphorus (D-P-). Thirty days after the beginning of treatment the animals showed low body weight, changes in the bone development, and decreased levels of 25-hydroxyvitamin D-3 (25-OH D-3). NK activity, evaluated using a cytotoxicity assay against Cr-51-labeled Yac.1 target cells, was not modified by the rickets-inducing treatment during the first 30 days. Following a long-term treatment (60 days) the rachitic rats (D-P-) exhibited higher NK activity than control animals (D + P +) (P < 0.05). on the other hand, D - P + animals showed higher cytotoxic activity than D - P - and D + P + groups. Feed replacement to the rachitic rats by a complete diet (D - P - /D + P +) led to a partial recuperation of growth, bone development, and 25-OH D-3 scrum. levels. The NK activity was also influenced by vitamin D intake, decreasing after treatment. (C) 2002 Elsevier B.V. B.V. All rights reserved. |
Formato |
183-189 |
Identificador |
http://dx.doi.org/10.1016/S0165-2478(02)00037-8 Immunology Letters. Amsterdam: Elsevier B.V., v. 81, n. 3, p. 183-189, 2002. 0165-2478 http://hdl.handle.net/11449/18035 10.1016/S0165-2478(02)00037-8 WOS:000175821700005 |
Idioma(s) |
eng |
Publicador |
Elsevier B.V. |
Relação |
Immunology Letters |
Direitos |
closedAccess |
Palavras-Chave | #immunity #natural killer #phosphorus #rickets #vitamin D |
Tipo |
info:eu-repo/semantics/article |