Propolis effect on streptozotocin-induced diabetic rats


Autoria(s): Sartori, D. R. S.; Kawakami, C. L.; Orsatti, C. L.; Sforcin, J. M.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/01/2009

Resumo

Propolis is one of the hive products that has been used extensively in folk medicine, due to its several biological and pharmacological properties. Besides, propolis-containing products have been intensely marketed by the pharmaceutical industry and health-food stores. This work was carried out in order to investigate whether propolis treatment could revert the metabolic alterations of streptozotocin-induced diabetic rats. Animals were kept in metabolic cages and diabetes was induced by a single dose of streptozotocin (35 mg/kg, IV). After a week, rats with glycemia higher than 230 mg/dL were divided into two groups and treated with ethanolic extract of propolis (10 and 90 mg/kg, PO) for seven days. Glycemia and free fatty acids were determined, as well as food and water intake, body weight and urine volume were registered weekly. Data showed no significant differences in the analyzed variables. Based on these results, one may conclude that propolis had no effects after diabetes establishment, in our conditions assays. Further assays with different concentrations of propolis and periods of administration should be carried out in order to evaluate its therapeutic potential in this disease.

Formato

93-102

Identificador

http://dx.doi.org/10.1590/S1678-91992009000100009

Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 15, n. 1, p. 93-102, 2009.

1678-9199

http://hdl.handle.net/11449/17798

WOS:000264366500009

S1678-91992009000100009.pdf

Idioma(s)

eng

Publicador

Universidade Estadual Paulista (UNESP), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)

Relação

Journal of Venomous Animals and Toxins Including Tropical Diseases

Direitos

openAccess

Palavras-Chave #Brazilian propolis #diabetes #glucose #free fatty acids
Tipo

info:eu-repo/semantics/article