Focus on Vitamin D, Inflammation and Type 2 Diabetes
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/01/2012
|
Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Processo FAPESP: 09/54395-0 Processo FAPESP: 10/08386-7 The initial observations linking vitamin D to type 2 diabetes in humans came from studies showing that both healthy and diabetic subjects had a seasonal variation of glycemic control. Currently, there is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response. Human studies investigating the impact of vitamin D supplementation on inflammatory biomarkers of subjects with or at high risk of developing type 2 diabetes are scarce and have generated conflicting results. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation. Future studies specifically designed to investigate the role of vitamin D on type 2 diabetes using inflammation as the main outcome are urgently needed in order to provide a more robust link between vitamin D, inflammation and type 2 diabetes. |
Formato |
52-67 |
Identificador |
http://dx.doi.org/10.3390/nu4010052 Nutrients. Basel: Mdpi Ag, v. 4, n. 1, p. 52-67, 2012. 2072-6643 http://hdl.handle.net/11449/17410 10.3390/nu4010052 WOS:000300718000005 WOS000300718000005.pdf |
Idioma(s) |
eng |
Publicador |
Mdpi Ag |
Relação |
Nutrients |
Direitos |
openAccess |
Palavras-Chave | #vitamin D #inflammation #diabetes |
Tipo |
info:eu-repo/semantics/article |