Dimorphism, thermal tolerance, virulence and Heat shock protein 70 transcription in different isolates of Paracoccidioides brasiliensis


Autoria(s): Theodoro, Raquel Cordeiro; Gimenes Bosco, Sandra de Moraes; Araujo, Joao Pessoa; Grisi Candeias, Joao Manuel; da Graca Macoris, Severino Assis; Trinca, Luzia Aparecida; Bagagli, Eduardo
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/06/2008

Resumo

The mycelia-to-yeast (M-Y) transition, thermal tolerance and virulence profiles were evaluated for nine isolates of Paracoccidioides brasiliensis, including samples from two of the three recently discovered cryptic species, as well as their relation to the partial sequence and transcription of the hsp70 gene. The isolates Bt84 and T10 (from PS2 species) took more time to convert to yeast form and presented elongated yeast cells at 36 degrees C. Arthroconidia production was also observed during the M-Y transition for some isolates. Our data confirm that the hsp70 transcription may be associated with thermal tolerance, but this does not seem to be directly related to high virulence profiles. The partial sequencing of this gene allowed the separation of our isolates into two clusters that correspond to the two sympatric cryptic species occurring in an area hyperendemic for PCM (Botucatu, SP, Brazil).

Formato

355-365

Identificador

http://dx.doi.org/10.1007/s11046-008-9091-6

Mycopathologia. Dordrecht: Springer, v. 165, n. 6, p. 355-365, 2008.

0301-486X

http://hdl.handle.net/11449/17113

10.1007/s11046-008-9091-6

WOS:000256091200001

Idioma(s)

eng

Publicador

Springer

Relação

Mycopathologia

Direitos

closedAccess

Palavras-Chave #cryptic species #dimorphism #hsp70 transcription #Paracoccidioides brasiliensis
Tipo

info:eu-repo/semantics/article