Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations


Autoria(s): Seiva, Fabio R. F.; Chuffa, Luiz Gustavo A.; Braga, Camila Pereira; Amorim, Joao Paulo A.; Fernandes, Ana Angelica H.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/10/2012

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Processo FAPESP: 02/03359-5

We reported the effects of quercetin on metabolic and hormonal profile as well as serum antioxidant activities in a model of MSG (monosodium glutamate)-induced obesity. Rats were divided into 4 groups: MSG group, submitted to neonatal treatment with high doses of MSG, administrated subcutaneously during 10 days, from 2 day-old; control groups, which received the same volume of saline. After completing 30 day-old, these groups were subdivided into 4 groups: control and MSG groups treated and non-treated with quercetin at doses of 75 mg/kg body weight (i.p.) over 42 days. BW gain and food consumption were higher in MSG treated rats and quercetin significantly reduced BW by 25%. While MSG increased triacylglycerol, total cholesterol and fractions, and reduced HDL concentrations, administration of quercetin normalized HDL-cholesterol and reduced others lipids. Insulin, leptin, glucose and creatinine levels were raised in MSG-treated rats and reduced after quercetin treatment. Alanine transaminase, aspartate transaminase, lactate dehydrogenase and alkaline phosphatase activities were lower after MSG-quercetin combination compared to rats given only MSG. MSG-quercetin combination augmented total protein and urea levels as well as glutathione peroxidase and superoxide dismutase activities in contrast to MSG-treated animals. Quercetin normalized serum lipid and glucose profile and minimized the MSG-related toxic effects, which was associated to its antioxidant properties. (C) 2012 Elsevier Ltd. All rights reserved.

Formato

3556-3561

Identificador

http://dx.doi.org/10.1016/j.fct.2012.07.009

Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 50, n. 10, p. 3556-3561, 2012.

0278-6915

http://hdl.handle.net/11449/16909

10.1016/j.fct.2012.07.009

WOS:000309897100025

WOS000309897100025.pdf

Idioma(s)

eng

Publicador

Pergamon-Elsevier B.V. Ltd

Relação

Food and Chemical Toxicology

Direitos

openAccess

Palavras-Chave #Monosodium glutamate #Lipid profile #Metabolism #Quercetin #Hepatoprotection #Antioxidant defenses
Tipo

info:eu-repo/semantics/article