Noradrenaline and mixed alpha(2)-adrenoceptor/imidazoline-receptor ligands: effects on sodium intake


Autoria(s): Sugawara, A. M.; Miguel, T. T.; de Oliveira, L. B.; Menani, José Vanderlei; De Luca, L. A.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

28/08/1999

Resumo

The effect of noradrenaline, and mixed ligands to alpha(2)-adrenoceptors (alpha(2)-AR) and imidazoline receptors (IR), injected intracerebroventricularly (i.c.v.), on sodium intake of sodium depleted rats, was tested against idazoxan, a mixed antagonist ligand to alpha(2)-AR and IR. The inhibition of sodium intake induced by noradrenaline (80 nmol) was completely reversed by idazoxan (160 and 320 nmol) injected i.c.v. The inhibition of sodium intake induced by mixed ligands to alpha(2)-AR and IR, UK14,304, guanabenz and moxonidine, was antagonized from 50 to 60% by idazoxan i.c.v. The results demonstrate that noradrenaline, a non-ligand for IR, acts on alpha(2)-AR inhibiting sodium intake. The possibility that either alpha(2)-AR or IR mediate the effect of mixed agonists on sodium intake remains an open question. (C) 1999 Elsevier B.V. B.V. All rights reserved.

Formato

227-234

Identificador

http://dx.doi.org/10.1016/S0006-8993(99)01695-9

Brain Research. Amsterdam: Elsevier B.V., v. 839, n. 2, p. 227-234, 1999.

0006-8993

http://hdl.handle.net/11449/16073

10.1016/S0006-8993(99)01695-9

WOS:000082449000003

Idioma(s)

eng

Publicador

Elsevier B.V.

Relação

Brain Research

Direitos

closedAccess

Palavras-Chave #adrenergic #imidazoline #sodium appetite #water intake #dehydration
Tipo

info:eu-repo/semantics/article