High incidences of DNA ploidy abnormalities in tongue squamous cell carcinoma of young patients: an international collaborative study
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
30/09/2013
20/05/2014
30/09/2013
20/05/2014
01/06/2011
|
Resumo |
Aims: This multi-centre analysis assessed the DNA content of TSCC in 37 young patients (<40 years) and 28 old patients (>50 years) and determined the correlation of DNA ploidy findings with clinicopathological data.Methods and results: Image cytometry was carried out using an automated cellular imaging system on Feulgen-stained histological sections to obtain high-fidelity DNA histograms. Among young patients, 37.8% were females compared to 18.7% in the older group (P = 0.002). In total, 48.6% patients were non-smokers and 40.5% were non-drinkers compared to 10.7% non-smokers and non-drinkers in the older group (P < 0.0001). TNM, clinical stage of disease and histological grade of differentiation did not differ between groups. Tumour aneuploidy was detected in 86.5% and tetraploidy in 24.3% young patients; this was significantly greater than in the older group where 64.3% were aneuploid (P < 0.0001) and 7.2% tetraploid (P < 0.0001). The mean values of DNA index (DI) and DNA heterogeneity index as well as the percentage of cells with DI exceeding 5N were higher in young patients (P < 0.0001).Conclusions: Young patients with TSCC represent a distinct clinical entity. The high incidence of DNA ploidy abnormalities suggest that they may have increased genomic instability and indicates underlying genetic differences between TSCC in young and older patients. |
Formato |
1127-1135 |
Identificador |
http://dx.doi.org/10.1111/j.1365-2559.2011.03863.x Histopathology. Malden: Wiley-blackwell, v. 58, n. 7, p. 1127-1135, 2011. 0309-0167 http://hdl.handle.net/11449/15650 10.1111/j.1365-2559.2011.03863.x WOS:000292108100015 |
Idioma(s) |
eng |
Publicador |
Wiley-Blackwell |
Relação |
Histopathology |
Direitos |
closedAccess |
Palavras-Chave | #aneuploidy #DNA-image cytometry #squamous cell carcinoma #tongue cancer #young adults |
Tipo |
info:eu-repo/semantics/article |