Histometric Analysis of Bone Repair in Bone-Implant Interface Using a Polylactic/Polyglycolic Acid Copolymer Associated With Implants in Rabbit Tibia


Autoria(s): Freire, Alexandre Rodrigues; Rossi, Ana Claudia; Queiroz, Thallita Pereira; Gulinelli, Jessica Lemos; Souza, Francisley Ávila; Margonar, Rogerio; Garcia-Junior, Idelmo Rangel; Hochuli-Vieira, Eduardo; Okamoto, Roberta
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

30/09/2013

20/05/2014

30/09/2013

20/05/2014

01/09/2012

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The purpose of this study was to evaluate the association of the combination of polylactic/polyglycolic acid around implants installed with and without primary stability through the histometric analysis of bone-implant interface. We used male rabbits, each of which received 2 titanium implants in each tibial metaphysis. The animals were divided into 4 groups: control with primary stability (CPS), control without primary stability (C), polymer with primary stability (PPS), and polymer without primary stability (P). Euthanasia was performed at postoperative days 40 and 90. The pieces were embedded in resin, sectioned, scraped, and stained with alizarin red and Stevenel blue. Histometric analysis evaluated the linear extension of contact between the bone and implant surface on the implant collar (CIC) and contact between the bone and implant surface on the first thread (CFT). Also evaluated was the area of newly formed bone (ANB) in the first thread. The results showed that there was new bone formation in all groups and during all periods. At 40 days, the ANB was higher in the PPS group than in the P group (P < .001); the CFT was statistically higher in the CPS group than the PPS group (P < .001) and was higher in the CPS group than the C group (P < .001). At 40 and 90 days, the CIC was higher in the P group than in the C group (P < .001). In conclusion, the copolymer had biocompatibility, enhanced bone healing, and presented osteoconductive properties, thus raising the contact between bone and implant, even without primary stability.

Formato

449-457

Identificador

http://dx.doi.org/10.1563/AAID-JOI-D-10-00102

Journal of Oral Implantology. Lawrence: Allen Press Inc, v. 38, n. 1, p. 449-457, 2012.

0160-6972

http://hdl.handle.net/11449/15131

10.1563/AAID-JOI-D-10-00102

WOS:000309024000003

Idioma(s)

eng

Publicador

Allen Press Inc

Relação

Journal of Oral Implantology

Direitos

closedAccess

Palavras-Chave #dental implants #bone substitutes #osseointegration #bone regeneration
Tipo

info:eu-repo/semantics/article