Effects of fluoride intake on insulin sensitivity and insulin signal transduction


Autoria(s): Chehoud, Keila Aziz; Chiba, Fernando Yamamoto; Sassaki, Kikue Takebayashi; Garbin, Clea Adas Saliba; Sumida, Doris Hissako
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

30/09/2013

20/05/2014

30/09/2013

20/05/2014

01/10/2008

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Processo FAPESP: 05/53301-1

Forty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered by gavage. After 30 min, the following experiments were performed: intravenous insulin tolerance test (0.75 U/kg bw) and determination of the insulin receptor substrate (pp 185-IRS-1/IRS/2) tyrosine phosphorylation status. The acute treatment with NaF promoted increased blood glycemia, but there were no significant changes in the insulin sensitivity and in the pp185 tyrosine phosphorylation status in the muscular or in the white adipose tissues.

Formato

270-275

Identificador

http://www.fluorideresearch.org/414/files/FJ2008_v41_n4_p00i-0iv.pdf

Fluoride. Ocean View: Int Soc Fluoride Research, v. 41, n. 4, p. 270-275, 2008.

0015-4725

http://hdl.handle.net/11449/14977

WOS:000263901900003

Idioma(s)

eng

Publicador

Int Soc Fluoride Research

Relação

Fluoride

Direitos

openAccess

Palavras-Chave #Insulin receptor substrate #Insulin sensitivity #Insulin signal #Plasma fluoride #Rats and insulin
Tipo

info:eu-repo/semantics/article