Action of nicotine and ovariectomy on bone regeneration after tooth extraction in rats
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
30/09/2013
20/05/2014
30/09/2013
20/05/2014
01/11/2010
|
| Resumo |
Purpose: The purpose of this study was to evaluate the effects of nicotine and ovariectomy on alveolar bone regeneration after exodontias in rats.Materials and Methods: For 30 days, sham ovariectomized (OVX)/NaCl, sham OVX/nicotine, OVX/NaCl, and OVX/nicotine animals were given 2 daily injections of saline or hemisulfate of nicotine. After this period, exodontic procedures were carried out and treatment continued up to the time of euthanasia on clays 7 and 14 when the alveoli were removed for further analyses.Results: The data confirmed that nicotine significantly delays the alveolar regeneration process after dental extraction in rats and showed that the association of nicotine with ovariectomy exacerbates these results.Conclusion: These results indicate that nicotine potentiated the effect of estrogen deficiency on bone regeneration induced by ovariectomy. (c) 2010 American Association of Oral and Maxillofacial Surgeons Oral Maxillofac Surg 68:2675-2681, 2010 |
| Formato |
2675-2681 |
| Identificador |
http://dx.doi.org/10.1016/j.joms.2010.04.018 Journal of Oral and Maxillofacial Surgery. Philadelphia: W B Saunders Co-elsevier Inc, v. 68, n. 11, p. 2675-2681, 2010. 0278-2391 http://hdl.handle.net/11449/14957 10.1016/j.joms.2010.04.018 WOS:000283971400006 |
| Idioma(s) |
eng |
| Publicador |
W B Saunders Co-elsevier Inc |
| Relação |
Journal of Oral and Maxillofacial Surgery |
| Direitos |
closedAccess |
| Tipo |
info:eu-repo/semantics/article |
