Influence of experimental inflammatory response on hepatic hepcidin gene expression and plasma iron concentration in sheep
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
30/09/2013
20/05/2014
30/09/2013
20/05/2014
15/05/2011
|
Resumo |
Hepcidin is a highly conserved disulfide-bonded peptide that plays a central role in iron homeostasis. During systemic inflammation, hepcidin up-regulation is responsible for hypoferremia. This study aimed to analyze the influence of the inflammatory process induced by complete Freund's adjuvant (CFA) or lipopolysaccharide (LPS) on the liver expression of hepcidin mRNA transcripts and plasma iron concentration of sheep. The expression levels of hepcidin transcripts were up-regulated after CFA or LPS. Hypoferremic response was observed at 12 h (15.46 +/- 6.05 mu mol/L) or 6 h (14.59 +/- 4.38 mu mol/L) and iron reached its lowest level at 96 h (3.08 +/- 1.18 mu mol/L) or 16 h (4.06 +/- 1.58 mu mol/L) after CFA administration or LPS infusion, respectively. This study demonstrated that the iron regulatory hormone hepcidin was up-regulated in sheep liver in response to systemic inflammation. These findings extend our knowledge on the relationship between the systemic inflammatory response, hepcidin and iron, and provide a starting point for additional studies on iron metabolism and the inflammatory process in sheep. (C) 2011 Elsevier B.V. All rights reserved. |
Formato |
157-161 |
Identificador |
http://dx.doi.org/10.1016/j.vetimm.2011.02.009 Veterinary Immunology and Immunopathology. Amsterdam: Elsevier B.V., v. 141, n. 1-2, p. 157-161, 2011. 0165-2427 http://hdl.handle.net/11449/14899 10.1016/j.vetimm.2011.02.009 WOS:000290188200021 |
Idioma(s) |
eng |
Publicador |
Elsevier B.V. |
Relação |
Veterinary Immunology and Immunopathology |
Direitos |
closedAccess |
Palavras-Chave | #Sheep #Hepcidin #Complete Freund's adjuvant #Lipopolysaccharide #Systemic inflammation #Hypoferremia |
Tipo |
info:eu-repo/semantics/article |