The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
20/05/2014
20/05/2014
01/01/2013
|
| Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Processo FAPESP: 10/08562-0 PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion. |
| Formato |
05-09 |
| Identificador |
http://dx.doi.org/10.1590/S0102-86502013000100002 Acta Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 05-09, 2013. 0102-8650 http://hdl.handle.net/11449/12842 10.1590/S0102-86502013000100002 S0102-86502013000100002 WOS:000313866600001 S0102-86502013000100002.pdf |
| Idioma(s) |
eng |
| Publicador |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| Relação |
Acta Cirúrgica Brasileira |
| Direitos |
openAccess |
| Palavras-Chave | #Acute Kidney Injury #Fluid Therapy #Colloids #Hetastarch #Rats |
| Tipo |
info:eu-repo/semantics/article |
