Human bcl-2 expression, cleaved caspase-3, and KSHV LANA-1 in Kaposi sarcoma lesions
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/11/2007
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Resumo |
We aimed to evaluate the frequency of Kaposi sarcoma (KS)-associated herpesvirus (KSHV) infection in KS lesions in patients from Brazil. In addition, expression of human bcl-2, cleaved caspase-3, and KSHV latency-associated nuclear antigen (LANA)-1 in tumors was evaluated using inummohistochemical analysis. We studied 64 KS cases, classified as follows: classical, 20 (31 %); iatrogenic, 2 (3 %); AIDS-associated, 25 (39%); and not otherwise specified (lack of information about HIV status), 17 (27%). KSHV was detected by polymerase chain reaction (PCR) in 61 cases (95%); 40 cases (63%) were KSHV+ by PCR and immunohistochemical analysis for LANA-L Immunoexpression of bcl-2 was detected in 47 cases (73%). Only a few cells in 15 cases (23%) of KS had demonstrable immunostaining for cleaved caspase-3. These results further support the association of KSHV with all KS forms. Cleaved caspase-3 in KS tumors was infrequent, which may reflect the inhibition of apoptosis owing to bcl-2 overexpression observed in the majority of KS tumors. |
Formato |
794-802 |
Identificador |
http://dx.doi.org/10.1309/TFU2FXK3AP0C9R2X American Journal of Clinical Pathology. Chicago: Amer Soc Clinical Pathology, v. 128, n. 5, p. 794-802, 2007. 0002-9173 http://hdl.handle.net/11449/12732 10.1309/TFU2FXK3AP0C9R2X WOS:000250310000012 |
Idioma(s) |
eng |
Publicador |
Amer Soc Clinical Pathology |
Relação |
American Journal of Clinical Pathology |
Direitos |
closedAccess |
Palavras-Chave | #Kaposi sarcoma #Kaposi sarcoma-associated herpesvirus #KSHV #human herpesvirus 8 #HHV-8 #latency-associated nuclear antigen 1 #cleaved caspase-3 #human bcl-2 |
Tipo |
info:eu-repo/semantics/article |