Experimental infection of Leishmania chagasi in immunosuppressed balb/c mice: cellular immune response and parasite burden
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/01/2008
|
Resumo |
The immune response to leishmaniasis can result in a polarization of a subpopulation of T lymphocytes, which leads to a different cell phenotype and results in immune protection or exacerbation of the disease. Leishmanias persist in the body both in asymptomatic infections and after treatment, representing risks in terms of immunosuppression. The objective of this study was to evaluate the effects of infection and immunosuppression by dexamethasone associated with pentoxifylline on animal weight, spleen weight, the parasitic load in the spleen and liver, as well as the production of IFN-gamma and IL-10 in spleen cell culture of Balb/c mice infected with Leishmania chagasi. The infection did not alter animal weight gain, but spleen weight and size increased. The immunosuppression, induced by dexamethasone associated with pentoxifylline, affected animal weight gain and weight and size of the spleen (in infected and not infected animals). The immunosuppression did not significantly alter the course of the parasite burden in the spleen and liver. Dexamethasone and pentoxifylline affected the studied cytokine production, but not influenced on Th1/Th2 response in infected animals. |
Formato |
751-751 |
Identificador |
http://dx.doi.org/10.1590/S1678-91992008000400017 Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 4, p. 751-751, 2008. 1678-9199 http://hdl.handle.net/11449/11857 S1678-91992008000400017 WOS:000267352500017 S1678-91992008000400017-en.pdf |
Idioma(s) |
eng |
Publicador |
Universidade Estadual Paulista (UNESP), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP) |
Relação |
Journal of Venomous Animals and Toxins Including Tropical Diseases |
Direitos |
openAccess |
Palavras-Chave | #Leishmania chagasi #immunosuppression #cell mediated response #parasite burden #experimental infection |
Tipo |
info:eu-repo/semantics/article |