Effects of Helicobacter pylori Infection on the Expressions of Bax and Bcl-2 in Patients with Chronic Gastritis and Gastric Cancer
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
20/05/2014
20/05/2014
01/01/2010
|
| Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Processo FAPESP: 05/56736-9 Processo FAPESP: 06/29925-0 The aim of the present study is to evaluate the influence of Helicobacter pylori on Bax and Bcl-2 mRNA and protein levels in patients with chronic gastritis and gastric cancer. The study included 217 patients, of which 26 were uninfected; 127 had chronic gastritis and were H. pylori-positive, and 64 had gastric cancer. Bacterial genotypes were evaluated by PCR, and the expression values were determined by quantitative real-time PCR and immunohistochemistry. Our data showed that the up-regulationary effects of H. pylori infection on the proapoptotic gene, Bax, were stronger than its induction of Bcl-2; this effect may increase apoptosis in patients with chronic gastritis. In patients with gastric cancer, the up-regulation of the anti-apoptotic gene, Bcl-2, counteracted the pro-apoptotic effects of Bax, leading to a deregulation of apoptosis-associated gene expression, favoring cell proliferation. Thus, the disturbance in Bax and Bcl-2 balance, induced by H. pylori, might be important in gastric cancer development. |
| Formato |
111-116 |
| Identificador |
http://dx.doi.org/10.1007/s10620-008-0699-7 Digestive Diseases and Sciences. Dordrecht: Springer, v. 55, n. 1, p. 111-116, 2010. 0163-2116 http://hdl.handle.net/11449/11410 10.1007/s10620-008-0699-7 WOS:000273520500018 |
| Idioma(s) |
eng |
| Publicador |
Springer |
| Relação |
Digestive Diseases and Sciences |
| Direitos |
closedAccess |
| Palavras-Chave | #Helicobacter pylori #Gastric cancer #Bax #Bcl-2 #Real-time PCR |
| Tipo |
info:eu-repo/semantics/article |
