Human breast tumor slices as an alternative approach to cell lines to individualize research for each patient
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/07/2012
|
Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Processo FAPESP: 05/55459-1 There are several breast cancer experimental models including cell lines, which are commonly used due to ease of handling and storage. However, the continued propagation of cell lines and distribution among laboratories results in genetic drift and distancing from the in-vivo model. Primary organ culture of breast cancer slices may produce biological responses with high standard deviation for different samples, reflecting the heterogeneity of different tumors. Thus, the organ culture model system offers a new perspective to the results obtained in the cell lines and offers an alternative for studies that seek to individualize treatment for each patient, an increasingly prominent concern in current cancer therapy. European Journal of Cancer Prevention 21:333-335 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. |
Formato |
333-335 |
Identificador |
http://dx.doi.org/10.1097/CEJ.0b013e32834dbc42 European Journal of Cancer Prevention. Philadelphia: Lippincott Williams & Wilkins, v. 21, n. 4, p. 333-335, 2012. 0959-8278 http://hdl.handle.net/11449/11401 10.1097/CEJ.0b013e32834dbc42 WOS:000304528400004 |
Idioma(s) |
eng |
Publicador |
Lippincott Williams & Wilkins |
Relação |
European Journal of Cancer Prevention |
Direitos |
closedAccess |
Palavras-Chave | #17 beta-estradiol #breast neoplasms #cell culture techniques #cell line #primary tumor slices culture #triiodothyronine #tumor |
Tipo |
info:eu-repo/semantics/article |