Toxicity of dietary restriction of fat enriched diets on cardiac tissue


Autoria(s): Diniz, Y. S.; Faine, L. A.; Almeida, J. A.; Silva, MDP; Ribas, B. O.; Novelli, ELB
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/12/2002

Resumo

The present study examines the effects of caloric restriction in cardiac tissue evaluation markers of oxidative stress. High-fat dietary restrictions can have a long-term impact on cardiac health. Dietary restriction of control diet increased myocardial superoxide dismutase (SOD) and catalase activities. Dietary restriction of fatty acid-enriched diets increased myocardial lipoperoxide concentrations, while SOD activity was decreased in cardiac tissue of rats with dietary restriction of fatty acid-enriched diets. Dietary restriction of unsaturated fatty acid-enriched diet induced the highest lipoperoxide concentration and the lowest myocardial SOD activity. Dietary restriction of unsaturated fatty acid decreased myocardial glycogen, and increased the lactate dehydrogenase/citrate synthase ratio. Dietary restriction of fatty acid-enriched diets were more deleterious to cardiac tissue than normal ad lib.-fed diet. In conclusion, the effects of caloric restriction on myocardial oxidative stress is dependent on which nutrient is restricted. Dietary restriction of fatty acid-enriched diets is deleterious relative to ad lib.-fed chow diet. (C) 2002 Elsevier, Science Ltd. All rights reserved.

Formato

1893-1899

Identificador

http://dx.doi.org/10.1016/S0278-6915(02)00172-2

Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 40, n. 12, p. 1893-1899, 2002.

0278-6915

http://hdl.handle.net/11449/11231

10.1016/S0278-6915(02)00172-2

WOS:000179599000019

Idioma(s)

eng

Publicador

Elsevier B.V.

Relação

Food and Chemical Toxicology

Direitos

closedAccess

Palavras-Chave #heart #dietary restriction #fatty acid #enzymes #oxidative stress
Tipo

info:eu-repo/semantics/article