Dexmedetomidine Alters the Cardiovascular Response During Infra-Renal Aortic Cross-Clamping in Sevoflurane-Anesthetized Dogs


Autoria(s): Braz, Leandro Gobbo; Braz, José Reinaldo Cerqueira; Castiglia, Yara Marcondes Machado; Galvaeo Vianna, Pedro T.; Vane, Luiz Antonio; Pinheiro Modolo, Norma S.; do Nascimento, Paulo; da Silva, Andre L.; Kinsky, Michael P.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/11/2008

Resumo

Some properties of the volatile anesthetics, such as vasodilatation and myocardial depression, combined with the sympathetic inhibition that alpha 2-agonists can produce may determine hemodynamic alterations during aortic, surgery. The interaction between dexmedetomidine (DEX), an alpha 2-agonist, and sevoflurane during aortic surgery is unknown. We studied the effects of DEX on hemodynamics and systemic oxygenation during aortic cross-clamping (Aox) and unclamping (UAox) in sevoflurane-anesthetized dogs Twenty dogs were. anesthetized with sevoflurane and were randomly assigned to two groups prior to Aox and UAox: control, n = 10, received saline infusion only, and DEX (1 mu g.kg(-1) load followed by 1 mu g.kg(-1).h(-1) infusion), n = 10. Hemodynamic and oxygenation variables were measured at baseline, after saline or DEX loading dose, 20 and 40 min after Aox, and 20 and 40 min after UAox. After DEX administration, heart rate, cardiac index l and systemic oxygen transport index (131021) were lower than in control group. Aox increased mean arterial pressure (MAP) and systemic vascular resistance index (SVRI) in both groups, but the effects were greater with DEX. Cl, heart rate, and DO(2)I were lower, while central venous pressure (CVP) and pulmonary artery occlusion pressure were higher in DEX compared to control. After UAox, MAP, CVP and SVRI were maintained higher in DEX in relation to control. We conclude that in sevoflurane-anesthetized dogs DEX alters the cardiovascular response during aortic surgery.

Formato

360-368

Identificador

http://dx.doi.org/10.1080/08941930802440803

Journal of Investigative Surgery. Philadelphia: Taylor & Francis Inc, v. 21, n. 6, p. 360-368, 2008.

0894-1939

http://hdl.handle.net/11449/10927

10.1080/08941930802440803

WOS:000262848100009

Idioma(s)

eng

Publicador

Taylor & Francis Inc

Relação

Journal of Investigative Surgery

Direitos

closedAccess

Palavras-Chave #dexmedetomidine #sevoflurane #aortic cross-clamping #hemodynamics #oxygen transport #dog
Tipo

info:eu-repo/semantics/article