Screening of Formulation Variables for the Preparation of Poly(epsilon-caprolactone) Nanocapsules Containing the Local Anesthetic Benzocaine
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
01/03/2011
|
Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Processo FAPESP: 06-00121-9 Processo FAPESP: 07/00127-0 In this work we describe the screening of four parameters in the preparation, by nanoprecipitation, of poly(epsilon-caprolactone) nanocapsules, used as a drug carrier system for the local anesthetic, benzocaine. A 2(4-1) factorial experimental design was used to study the influence of four different independent variables (polymer, oily phase, Span 60 and Tween 80) on nanocapsule characteristics (size, polydispersion index, zeta potential) and drug loading capability. Best results were obtained using an aqueous formulation comprising 100 mg of polymer, 200 mg of oily phase, 40 mg of Span 60 and 60 mg of Tween 80 in a final volume of 10 mL which produced a colloidal system with particle size of 188 nm, zeta potential -32 mV, polydispersion index 0.07, and benzocaine association efficiency > 87%. These findings open the way for future clinical studies using such formulations. |
Formato |
2450-2457 |
Identificador |
http://dx.doi.org/10.1166/jnn.2011.3547 Journal of Nanoscience and Nanotechnology. Stevenson Ranch: Amer Scientific Publishers, v. 11, n. 3, p. 2450-2457, 2011. 1533-4880 http://hdl.handle.net/11449/10130 10.1166/jnn.2011.3547 WOS:000288102300090 |
Idioma(s) |
eng |
Publicador |
Amer Scientific Publishers |
Relação |
Journal of Nanoscience and Nanotechnology |
Direitos |
closedAccess |
Palavras-Chave | #Experimental Design #2(4-1) Factorial Experimental #Nanoparticles #Polymeric Nanocapsules #Local Anesthetic |
Tipo |
info:eu-repo/semantics/article |