Bed nucleus of the stria terminalis and the cardiovascular responses to chemoreflex activation
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
20/05/2014
20/05/2014
03/04/2012
|
Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Processo FAPESP: 10/17343-0 Processo FAPESP: 09/03187-9 Several studies from our group have indicated that the BNST play an important role in baroreflex modulation. However, the involvement of the BNST in the chemoreflex activity is unknown. Thus, in the present study, we investigated the effect of the local bed nucleus of stria terminalis (BNST) neurotransmission inhibition by bilateral microinjections of the non-selective synaptic blocker cobalt chloride (CoCl2) on the cardiovascular responses to chemoreflex activation in rats. For this purpose, chemoreflex was activated with KCN (i.v.) before and after microinjections of CoCl2 into the BNST. Reversible BNST inactivation produced no significant changes in the magnitude and durations of both pressor and bradycardic responses to intravenous KCN infusion. These findings suggesting that BNST neurotransmission have not influence on both sympathoexcitatory and parasympathoexcitatory components of the peripheral chemoreflex activation. (C) 2012 Elsevier B.V. All rights reserved. |
Formato |
21-26 |
Identificador |
http://dx.doi.org/10.1016/j.autneu.2011.11.004 Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 167, n. 1-2, p. 21-26, 2012. 1566-0702 http://hdl.handle.net/11449/8135 10.1016/j.autneu.2011.11.004 WOS:000301947900005 WOS000301947900005.pdf |
Idioma(s) |
eng |
Publicador |
Elsevier B.V. |
Relação |
Autonomic Neuroscience-basic & Clinical |
Direitos |
openAccess |
Palavras-Chave | #Autonomic nervous system #CoCl2 #KCN #Cardiovascular system #Blood pressure #Heart rate |
Tipo |
info:eu-repo/semantics/article |