Bed nucleus of the stria terminalis and the cardiovascular responses to chemoreflex activation


Autoria(s): Granjeiro, Erica M.; Gomes, Felipe V.; Alves, Fernando H. F.; Crestani, Carlos Cesar; Correa, Fernando M. A.; Resstel, Leonardo B. M.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

03/04/2012

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Processo FAPESP: 10/17343-0

Processo FAPESP: 09/03187-9

Several studies from our group have indicated that the BNST play an important role in baroreflex modulation. However, the involvement of the BNST in the chemoreflex activity is unknown. Thus, in the present study, we investigated the effect of the local bed nucleus of stria terminalis (BNST) neurotransmission inhibition by bilateral microinjections of the non-selective synaptic blocker cobalt chloride (CoCl2) on the cardiovascular responses to chemoreflex activation in rats. For this purpose, chemoreflex was activated with KCN (i.v.) before and after microinjections of CoCl2 into the BNST. Reversible BNST inactivation produced no significant changes in the magnitude and durations of both pressor and bradycardic responses to intravenous KCN infusion. These findings suggesting that BNST neurotransmission have not influence on both sympathoexcitatory and parasympathoexcitatory components of the peripheral chemoreflex activation. (C) 2012 Elsevier B.V. All rights reserved.

Formato

21-26

Identificador

http://dx.doi.org/10.1016/j.autneu.2011.11.004

Autonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 167, n. 1-2, p. 21-26, 2012.

1566-0702

http://hdl.handle.net/11449/8135

10.1016/j.autneu.2011.11.004

WOS:000301947900005

WOS000301947900005.pdf

Idioma(s)

eng

Publicador

Elsevier B.V.

Relação

Autonomic Neuroscience-basic & Clinical

Direitos

openAccess

Palavras-Chave #Autonomic nervous system #CoCl2 #KCN #Cardiovascular system #Blood pressure #Heart rate
Tipo

info:eu-repo/semantics/article