No relationship found between point heteroplasmy in mitochondrial DNA control region and age range, sex and haplogroup in human hairs


Autoria(s): de Camargo, Maria Angelica; Paneto, Greiciane G.; de Mello, Aline C. O.; Martins, Joyce A.; Barcellos, William; Cicarelli, Regina Maria Barretto
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

20/05/2014

20/05/2014

01/02/2011

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Processo FAPESP: 05/03984-5

Processo FAPESP: 07/05647-1

The analysis of heteroplasmy (presence of more than one type of mitochondrial DNA in an individual) is used as a tool in human identification studies, anthropology, and most currently in studies that relate heteroplasmy with longevity. The frequency of heteroplasmy and its correlation with age has been analyzed using different tissues such as blood, muscle, heart, bone and brain and in different regions of mitochondrial DNA, but this analysis had never been performed using hair samples. In this study, samples of hair were sequenced in order to ascertain whether the presence or not of heteroplasmy varied according to age, sex and origin of haplogroup individuals. The samples were grouped by age (3 groups), gender (male and female) and haplogroup of origin (European, African and Native American), and analyzed using the chi-square statistical test (chi(2)). Based in statistical results obtained, we conclude that there is no relationship between heteroplasmy and sex, age and haplogroup origin using hair samples.

Formato

1219-1223

Identificador

http://dx.doi.org/10.1007/s11033-010-0220-1

Molecular Biology Reports. Dordrecht: Springer, v. 38, n. 2, p. 1219-1223, 2011.

0301-4851

http://hdl.handle.net/11449/7893

10.1007/s11033-010-0220-1

WOS:000286472600065

Idioma(s)

eng

Publicador

Springer

Relação

Molecular Biology Reports

Direitos

closedAccess

Palavras-Chave #Heteroplasmy #Mitochondrial DNA #Hair #Age #Sex #Haplogroup
Tipo

info:eu-repo/semantics/article